Unfortunately, you can't rely upon "computer stores" to have the correct info on multi-card setups. I'm almost 100% sure... you can run multi-card on ANY mobo with proper slots and where the BIOS allows. Some mobos have "SLI" capability, and if that option is selected, you can't run multi-monitors while that feature is enabled. So, just don't enable that feature. Any X58 mobo with at least 2, x16 slots should work for you.