I use RegSupreme by Macecraft everyday of every week and never had one problem... even when i use the deep reg clean setting... have not needed to re-install windows for two and half years... also use PerfectDisk for defrag and Adaware to clean spy stuff...
Why put this in Chit-Chat? I had this happen to me before. If you start a thread on Linux, it gets moved to Chit-Chat.