From the CDC exercise guidelines "People who sit a lot have an increased risk of all-cause and cardiovascular disease mortality, as well as an increased risk of developing cardiovascular disease, type 2 diabetes, and colon, endometrial, and lung cancers. The mortality risk related to sitting is not observed among people who do 60 to 75 minutes of moderateintensity physical activity a day, but this amount of activity is far more than most people obtain. Therefore, both reducing sitting time and increasing physical activity will provide benefts. " https://health.gov/sites/default/files/2019-09/Physical_Activity_Guidelines_2nd_edition.pdf