NR and NAD+

Discussion in 'Health and Fitness' started by Pekelo, Dec 31, 2018.

  1. Pekelo


    If you have been searching for The Fountain of Youth, search no more... First the science part:

    Now say it after me: Nicotinamide Riboside

    What is Nicotinamide Riboside?
    Nicotinamide riboside is a form for vitamin B3 that has been shown to increase levels of nicotinamide adenine dinucleotide (a.k.a NAD+). Nicotinamide riboside is not the same as the other forms of vitamin B3, nicotinic acid (niacin) & nicotinamide.

    Here are each of the forms in which vitamin B3 is found:

    • Nicotinic acid
    • Nicotinamide
    • Nicotinamide riboside
    Buyer's guide:

    The potential beneficial functions of nicotinamide riboside are as follows:

    • Improves muscle function
    • Fights cancer and brain diseases like Alzheimer’s
    • Protects the brain, liver and mitochondria
    • Decreases symptoms of diabetes
    • Helps to prevent hearing loss
    • Increases metabolism
    • Helps with weight loss
    • Extends lifespan
    • Regulates the circadian rhythm, or sleep cycle
    NAD+ is in every living cell in the human body and plays a role in metabolism, DNA repair and cell signaling. Pre-clinical trials have shown NAD+ to have anti-aging properties and it helps to generate energy in tissues such as muscle, liver and brain. Nicotinamide riboside is one of NAD+ precursors and helps to bypass the enzyme called NAMPT which is a rate limiting enzyme for creating NAD+.
  2. destriero


    I have taken it for just over two years. I haven’t noticed any benefits (telomeres).
  3. Baron

    Baron ET Founder

    Oh great. I just bought some last week. :banghead:
  4. Pekelo


    Which one did you buy? (there is one on Amazon mixed with resveratrol) Gives us feed back on its effect after a week or so, will you?
  5. destriero


  6. Baron

    Baron ET Founder

    I bought Tru Niagen straight from their own website. I will report back for sure.
  7. Pekelo


    This is a 22 months long experiment by an MD. He lost 50 lbs without exercise or calorie restriction, his memory got better. Better sleep too. Very interesting video. The before and after pics say everything...

    Dave Oatway3 months ago
    I have been following essentially the same regimen for over 2 years. At age 73 I hiked 30 miles of the Inca trail at 12000 feet with several much! younger companions and had no issues. I have lost over 20 pounds of weight, no longer have a fatty liver, and feel better than I did at age 40. So I add a partial n of 1 to your observations. Thank you for the video. BTW I take Metformin 500 mg qd, 500 mg Niacin bid, and Crestor 2 mg qd.
    Last edited: Dec 31, 2018
  8. Pekelo


    Now this is an interesting comment:

    E O7 months ago
    In the Journal Cell Metabolism this month (Quantitative Analysis of NAD Synthesis-Breakdown Fluxes. Cell Metabolism 2018; 27: pp 1067-1080) in a mice/rodent model, nicotinamide mononucleotide and nicotinamide riboside when taken orally were metabolized to nicotinamide in the liver. The conclusion of this study is that the two supplements are very expensive versions of simple nicotinamide ( inexpensive and widely available) and provide no additional benefit again validating the recommendations in this presentation.


    I happen to have Nicotinamide home, the wife ordered it some time ago. I did start to take it 2 days ago. Right now I am taking 4-5 different things (usually it is just 2-3) so it is harder to pinpoint what causes the good effects, but will report back...
    Trinfinity8 isn’t likely to help, But research on Cellular metabolism might yield results
    • Montreal Gazette
    • 8 Sep 2018
    • JOE SCHWARCZ Joe Schwarcz is director of McGill University’s Office for Science & Society ( He hosts The Dr. Joe Show on CJAD Radio 800 AM every Sunday from 3 to 4 p.m.
    Clues to slow aging are likely to come from delving into the intricacies of cellular metabolism, the set of chemical reactions occurring in cells that are needed to maintain life.

    Perhaps the oldest formula for trying to beat the aging process can be found in an Egyptian papyrus dating back to circa 1500 BC. The Edwin Smith Papyrus features a Recipe for Transforming an Old Man into a Youth that involves rubbing the body with a dried “hemayet” fruit to remove “all weaknesses which are in the flesh.” Unfortunately, nobody has been able to identify what the hemayet fruit is.

    Fast forward to present day, and instead of fruit, we find fruitloopery. That’s the use of scientific language in a meaningless way to foster belief in some nutty concept. A classic example is Trinfinity8, an $8,000 anti-aging system that features two crystal rods attached to a “digital translator device” that plugs into the USB port of a computer loaded with special software. Grabbing the rods will “transmit healing codes through the nerves, meridians and minor chakras of your hands, flooding your system with streams of rejuvenating information.” The codes are based on “vibrational energies and fractal formulations that are in harmony with core energetics that encompass all of nature.”

    Who says so? Clinical psychologist Kathy Forti, who in 2003 had an out of body experience during which she encountered “multi-dimensional beings” who advised her to focus on quantum physics. She knew nothing about the subject, or about electronics, but somehow her guides transmitted the critical knowledge that led to the development of a “Fractal Amplification Resonator” that is an essential part of the Trinfinity8 system that “makes it different from other bio-energetic devices.” It “represents

    a new quantum shift in the emerging science of algorithmic rejuvenation technology” and sets up a “vibratory loop.”

    This fruitloopiness makes my brain vibrate. I need to calm it down with some research that may actually bear fruit.

    Clues to retard aging are likely to come from delving into the intricacies of cellular metabolism, the set of chemical reactions occurring in cells that are needed to maintain life. These reactions are broadly divided into two classes, “anabolism” and “catabolism.” In anabolism, a cell uses energy to construct molecules such as enzymes, structural proteins, neurotransmitters and nucleic acids, all of which perform essential functions. Catabolism is the metabolic process by which the cell breaks down complex molecules such as fats, carbohydrates and proteins to provide the energy and components needed by anabolic reactions. The maintenance of efficient cellular metabolism plays a pivotal role in life expectancy and the prevention of ageassociated disease.

    The most compelling studies for preventing metabolic reactions from faltering have involved calorie restriction. Whether in yeast cells, roundworms, rodents or monkeys, reducing calorie intake increases longevity. The question is by what mechanism? One theory is that calorie restriction activates a gene known as SIRT1 (Silent Information Regulator Type 1) that codes for a protein called “sirtuin1.” This protein catalyzes a host of important metabolic reactions such as those involved in DNA repair, control of inflammation and regulation of insulin sensitivity. While the production of this protein is guided by the SIRT1 gene, the process also requires a “coenzyme” called “nicotinamide adenine dinucleotide (NAD+).” This compound also performs a variety of other functions, such as playing a critical role in the production of ATP, the cell’s energy currency. As we age, levels of NAD+ in the body decline.

    Understandably then, there is a great deal of interest in dietary supplements of NAD+, as well as in the precursor from which the body makes it, namely “nicotinamide riboside.” One version, Basis, developed by Elysium Health, combines nicotinamide riboside with pterostilbene, a compound found in blueberries that is also thought to activate the SIRT1 gene. The company doesn’t promote Basis as a product that increases life expectancy, but rather as a supplement to increase “healthspan.” That may sound hokey, but it does merit further consideration because the co-founder of Elysium Health is MIT professor Leonard Guarente, a highly respected researcher on aging.

    In 2017, Guarente and colleagues published a paper in Nature, a top-notch journal, that reported on a trial in 120 adults between the ages of 60 and 80 who were given either a placebo or a combination of a single or double dose of nicotinamide riboside with pterostilbene over an eight-week period. Blood levels of NAD+ increased by 40 per cent in the single dose group and by 90 per cent in the double dose group. No side effects were noted.

    While this is an interesting study, it does not justify the promotion of any supplement that features either NAD+ or nicotinamide riboside as having antiaging benefits. Demonstrating an elevation of NAD+ is not the same as demonstrating clinical benefit. That requires a randomized, controlled, double-blind trial in which health outcomes are evaluated. What we have so far is a plausible theory that begs for clinical evidence. But at least it isn’t fruitloopery.
  10. Pekelo


    10 days later we would like to hear a progress report, if you don't mind.
    #10     Jan 10, 2019