and see all those Canadians piling up at the border? Just Kidding. We should trade them for Whistler Blackcomb.
Alaska becomes 1st state to remove eligibility requirements for COVID-19 vaccine https://theweek.com/speedreads/9712...move-eligibility-requirements-covid19-vaccine Officials in Alaska shared some good news on Tuesday evening, announcing that anyone 16 and older who lives or works in the state is now eligible for the COVID-19 vaccine. Alaska is the first state to drop eligibility requirements for the vaccine, giving access to all. Previously, health care workers, educators, and senior citizens were given top priority, followed by people who work essential jobs, those at risk for developing a serious illness from COVID-19, and anyone 55 or older. "Soon, this virus will be a preventable disease if people choose to get vaccinated," Dr. Anne Zink, Alaska's chief medical officer, said. Gov. Mike Dunleavy (R), who tested positive for COVID-19 last month, told reporters he believes "we'll get enough Alaskans that want to be part of this process that we're going to put this behind us as quickly as possible." Alaska has the country's highest COVID-19 vaccination rate, with 25 percent of the population at least partially vaccinated, compared to the national average of 18 percent,theAnchorage Daily Newsreports.Catherine Garcia
What needs to be added in with that article is that Alaska started having significant instances where they had excess vaccine at sites so they moved to making it eligible to all while still prioritizing. Which is a good move. Not necessarily the right move for other states. If you announce eligibility for all too soon without the vaccine to go with it, it can get chaotic. Califorinia/Pasadena has a little disaster going there in that department. They are a line-jumping culture already without opening it up to more. Pasadena Cancels COVID-19 Vaccine Clinic After Slots Filled by Hollywood and Media Employees https://variety.com/2021/film/news/...-clinic-hollywood-media-employees-1234926792/
Not going well with the AstraZeneca vaccine. Remember that the EU countries trashed the mRNA vaccines as risky and wanted a "traditional" vaccine. Setting the table for their lack of supply and issues today... Denmark, Norway, Iceland, Italy halt use of AstraZeneca vaccine due to safety concerns https://www.france24.com/en/video/2...of-astrazeneca-vaccine-due-to-safety-concerns
COVID-19 brings a new dawn for messenger RNA vaccines https://www.axios.com/whats-next-for-rna-vaccines-eeb8a8f7-d7e1-4538-8f3b-05a8742ba6ec.html The blockbuster success of messenger RNA vaccines in the COVID-19 pandemic could give a boost to efforts to use the technology to tackle cancers, malaria and other intractable illnesses. Why it matters: There's a pressing need for new ways to prevent infection from viruses like HIV and influenza that conventional vaccines have struggled to address and to treat rare genetic diseases and cancers that kill millions each year. Vaccines and therapies based on messenger RNA (mRNA) hold promise as a solution, but the technology is still in its infancy. "The pandemic has alerted the world to how good this platform is," says Drew Weissman, an immunologist at the University of Pennsylvania whose research underpins the mRNA COVID-19 vaccines by Moderna and Pfizer-BioNTech. "It will hopefully make future studies and approvals easier." The basics: In every cell in your body, mRNA carries instructions for making proteins from one part of the cell to another. Proteins — a broad class of molecules that includes antibodies, enzymes and some hormones — are at the center of the immune system's response to viral and bacterial invaders and, when a protein malfunctions, disease can result. Vaccines and therapies that use mRNA can, in theory, be used to train the immune system to recognize invaders and aberrations and correct or restore proteins involved in a host of diseases. But the technology faces hurdles around its delivery within the body, its effectiveness against some diseases and its production. The list of diseases mRNA vaccine technology could be applied to is "enormous," Weissman says. It includes infectious diseases like malaria and influenza. And cystic fibrosis, sickle cell anemia and cancers are all potential targets for mRNA-based therapies. But some conditions — like diabetes, which results from misregulation of insulin in the body — may not be ripe for mRNA therapy because "we don't have control over how much protein is produced by the RNA," Weissman says. How it works: Vaccines based on mRNA carry the instructions for making antigen proteins found on the surface of a virus into the body's cells. Those antigens are then made by the cells and in turn prime the immune system to protect the host if the virus attacks. With mRNA therapies, the goal in cases like cystic fibrosis may be to restore the properfunction of a protein, whereas in others, mRNA could be a way to deliver replacement proteins or gene-editing enzymes to treat genetic diseases before birth. Where it stands: After decades of development and several setbacks for mRNA vaccines, two are now being actively deployed to fight COVID-19.And pharmaceutical companies are pursuing others. Moderna, for example, has 24 mRNA vaccines in development, and in January, the company announced it was pursuing three new vaccines: for HIV, seasonal flu and the Nipah virus, which causes encephalitis and has a fatality rate as high as 75%. Clinical trials — one for a seasonal influenza vaccine, another for a universal flu vaccine, a vaccine for genital herpes and two for HIV — are underway at Penn, Weissman says. The effectiveness and safety of COVID-19 mRNA vaccines and their delivery to millions of people during the pandemic have "tremendously accelerated" the technology, says Sarah Fortune, a professor of immunology and infectious disease at Harvard who studies tuberculosis. She and others are taking advantage of the speed at which mRNA vaccines can be made by plugging in mRNA sequences to make vaccines that trigger different levels of immune response, allowing researchers to home in on sweet spots for diseases like TB where too strong an immune response can be dangerous. What's next: Researchers are trying to use mRNA for therapies for noninfectious diseases that can't be prevented with a vaccine. For cancer, mRNA is being investigated as a way to deliver to cells the code for proteins in a tumor, which could even be personalized to match an individual's cancer mutations. The cells then produce those proteins, training the immune system to recognize and destroy the cancer. Some early results are promising, but its success has been limited in other studies. The challenges: It can be difficult to direct mRNA to specific organs and types of cells, and for cancers and other noninfectious diseases, location matters. Weissman told MIT Tech Review's Antonio Regalado he's come up with a solution to get the nanoparticles that carry mRNA to bone marrow stem cells and he hopes to use it to deliver gene therapy for sickle cell anemia. More broadly, another challenge is likely to be tissue-level immunity, says Fortune, pointing to tuberculosis, an infection of the lungs, which "have many mechanisms to tamp down the immune response so it doesn’t go crazy. It's unclear whether mRNA vaccines will intersect with those tissue level immune regulatory systems." The fragility of mRNA also means there can be strict manufacturing and storage needs. And the full cost of treatments is unknown — large-scale manufacturing of mRNA vaccines is still being optimized and, despite their pandemic moment, "RNA vaccines might yet face financial headwinds," Elie Dolgin writes for Nature News. The bottom line: There will be hurdles in getting mRNA technology to work in humans for different diseases, Weissman says. "There's a lot we don't know."
The Euros are refusing to take the AZ vaccine and it’s putting a damper on the whole global effort. Furthermore, we in the US, have a substantial amount of AZ doses sitting around for an EAU that we most likely will not give but are probably holding off because we don’t want to upset the rest of the world that already authorized its use. It’s just a big mess with the AZ vaccine because with the Euros balking and us not authorizing it yet.