https://www.elitetrader.com/et/thre...d-denier-nonsense.362220/page-45#post-5756969 Recently Project Veritas has put out a video making claims about the Pfizer Covid vaccine. Of course, just like most of their other recent material, it has turned out to be pure bullshiat. Let's take a closer look. Breaking Down the Project Veritas Video About Pfizer Purportedly Exploring 'Mutating' COVID-19 Pfizer published a response to the claims on the company's website. We were unable to establish contact with Jordon or Jordan Trishton Walker. https://www.snopes.com/news/2023/01/31/project-veritas-pfizer-mutating-covid/ Video of Pfizer Employee Explaining COVID Vaccine Research Debunked https://www.medpagetoday.com/special-reports/exclusives/102895?trw=yes&hr=kmd
Drug companies face COVID cliff in 2023 as sales set to plummet https://www.reuters.com/business/he...ovid-cliff-2023-sales-set-plummet-2023-02-06/ NEW YORK, Feb 6 (Reuters) - Pharmaceutical companies that made billions from the pandemic over the past two years selling vaccines and treatments are now up against a steep COVID cliff and investor pressure to spend their windfalls wisely. Western drugmakers including Pfizer Inc (PFE.N), BioNTech SE (22UAy.DE), Moderna Inc (MRNA.O), Gilead Sciences Inc (GILD.O), AstraZeneca Plc (AZN.L) and Merck & Co (MRK.N) are estimated to have brought in about $100 billion in revenue from COVID vaccines and treatments in 2022. Company and analyst estimates suggest those sales could fall by nearly two-thirds this year due to built up product inventories around the world including in the countries that pay the most. Population immunity from high rates of vaccination and previous infections means that demand for treatments could dip as well. These companies are used to steep revenue drops known as patent cliffs that occur when their exclusivities on big-selling drugs expire and generic rivals move in, but they strategize for those swings for years. "When you think about traditional drug and vaccine development and longevity of sales, it's usually much more spread out," Morningstar analyst Damien Conover said. "This is very, very concentrated." The sudden inflow of revenue should prod companies to strike deals and link up with new partners, he said. BMO Capital Markets analyst Evan Seigerman said companies should use the quick cash for transformative deals. "Pfizer did these $10 billion deals to build their portfolio and I think they need to do something bigger and more impactful," he said, referring to the $5.4 billion buyout of Global Blood Therapeutics and $11.6 billion purchase of migraine drugmaker Biohaven Pharmaceutical. Pfizer has been the biggest corporate beneficiary of the pandemic financially, with more than $56 billion in 2022 revenue from the vaccine it developed with German partner BioNTech and from its COVID-19 antiviral treatment Paxlovid. Pfizer has said it expects that revenue to drop to around $21.5 billion in 2023, although some analysts believe that forecast is overly optimistic. "We remain skeptical that COVID revenues will grow in 2024 and beyond," JP Morgan analyst Chris Schott said in a research note, adding that vaccination rates could fall even further than the significant decline seen with booster shots in 2022. Vaccine maker Moderna also expects 2023 revenue to fall sharply. The company's only product - its messenger RNA COVID vaccine - pulled in around $18.4 billion in 2022. Analysts expect that to drop to around $7 billion in 2023. The company is due to report earnings later this month. Oppenheimer & Co analyst Hartaj Singh said investors are "frustrated Moderna hasn't used their firepower more effectively to prepare for revenues and earnings going down in 2023 or 2024." Moderna shares are up in recent months, but a $173.25 closing price on Friday is more than 65% off their pandemic high of close to $500 in August 2021. "There are examples of companies that have sat on their hands and the share price has not done well, and Moderna could go down that path," Singh cautioned. MERCK, LILLY PLAN FOR DECLINE Other companies have seen a more modest impact from their COVID businesses. "We are not counting on Lagevrio as a driver of growth for our business," Merck Chief Executive Rob Davis said in an interview last week of the company's antiviral pill. "We very much saw Lagevrio as an opportunity to make a meaningful difference at a time of need." Merck reported sales of $5.7 billion from the treatment last year. Analysts expect that to drop below $1 billion this year. Merck had over $59 billion in total sales in 2022. Eli Lilly and Co (LLY.N) made $2 billion in 2022 from monoclonal antibody COVID treatments and is not expecting any revenue from the business in 2023. The U.S. Food and Drug Administration pulled its authorization of Lilly's latest antibody bebtelovimab in November because it was not effective against circulating Omicron subvariants. "We did fine with COVID," Eli Lilly CEO Dave Ricks said in an interview. "We made a little bit of money with it. What we did with that was we mostly reinvested it in R&D (Research and Development), and last year was a record R&D spending year for the company."
The Medicago shutdown impacted the RTP area in North Carolina as well. Vaccine maker in RTP shuts down in wake of layoffs https://www.bizjournals.com/triangl...go-shutting-down-operations-rtp-facility.html
Any business basing its only productive product line on Covid Vaccines when the Pandemic is very close to becoming an official Endemic... it's a business that will not last too long. Yet, I thought this company was betting big on monoclonal antibodies for the FLU and Ebola diseases ? Maybe this is more of a stock performance discussion. Was it ever listed ? Simply, if I was a stock trader...I would Short it. wrbtrader
This story covers a shot which is not a vaccine but a treatment for Covid which is showing promise. It is a form of interferon anti-viral. A One-Shot COVID-19 Treatment Shows Promise https://time.com/6254030/single-shot-covid-19-treatment/ The current medicine chest for treating COVID-19 is fairly sparse. Only one drug—remdesivir—is approved by the U.S. Food and Drug Administration (FDA), and three—Paxlovid, molnupiravir, and convalescent plasma—have emergency use authorization from the FDA. With new variants of the virus continuing to emerge, developing next-generation treatments is a top priority. One such therapy could be interferon lambda. In a study published Feb. 8 in the New England Journal of Medicine, researchers led by Dr. Jeffrey Glenn at Stanford University report that a single injection of that drug within three days of of the first symptoms reduced hospitalizations for COVID-19 by 51%, and deaths by 50%, among vaccinated people. The benefits are even greater among unvaccinated people, with hospitalization drops of 80% or more, putting it on par with Paxlovid. “It’s really exciting data,” says Glenn, the study’s senior author. How it works Interferon lambda is an antiviral that works on several levels during a viral infection: by killing invading viruses and warning uninfected cells to set up their defenses against infection. The compound is therefore active against a number of different viruses. It’s been studied most extensively at Eiger BioPharmaceuticals—which tested and makes the drug, and which Glenn founded and maintains an equity stake in—against the hepatitis D virus, which causes liver disease. (Studies involving the drug for that virus are ongoing.) The current study involved nearly 2,000 people in Brazil and Canada and took place from June 2021 to February 2022, when several different variants were circulating, including Delta and the first versions of Omicron. About half of the participants were given the drug, and half a placebo. Because the treatment requires only a single shot administered by a doctor, compliance was 100%, and researchers observed minimal side effects. By contrast, the oral treatment Paxlovid requires people to take dozens of pills over five days, and may have adverse interactions with some commonly prescribed medications, including some cholesterol-lowering statin drugs. The researchers found that interferon lambda had similarly high antiviral activity against all of the variants tested, a promising drug trait against an ever-evolving virus. Interferon lambda’s broad antiviral effect also means it could potentially be a useful therapy against a number of different viruses beyond SARS-CoV-2 and hepatitis D, including influenza, Glenn says. He hopes a future study will put that possibility to the test with a trial in which people with symptoms like fever, cough, and muscle aches would be randomly assigned to receive interferon lambda or placebo even before they were tested to figure out which viral infection they have, so scientists could learn more about the extent of the drug’s efficacy as a broad-spectrum antiviral treatment. “Now, if you go to the doctor and tests show you have a virus, you’re generally told to go home,” Glenn says. “But imagine if instead you get a shot of lambda. It wouldn’t matter what you have, whether it was COVID-19, RSV or influenza, all of those viruses should be sensitive to lambda.” At least, that’s the hope, which needs to be borne out by more studies. The researchers believe that interferon lambda could also slow or even keep the virus from mutating to become resistant to other antiviral treatments, such as Paxlovid and molnupiravir. A recent study showed that SARS-CoV-2 has already begun to develop resistance to molnupiravir, which isn’t uncommon for antiviral drugs. And lab studies have found several pathways by which the virus mutates to escape Paxlovid. (Anti-HIV medications, for instance, commonly develop resistance to that virus.) Treating people with a combination of antivirals that includes interferon lambda could theoretically suppress viral escape, says Glenn—another intriguing assertion that needs to be tested. “If we see widespread resistance to Paxlovid, we’ll be in big trouble,” he says. “But one of the ways to decrease the likelihood of that happening is to combine it with an interferon like lambda. Both drugs have high response rates, and if you combine them, you should get even higher response rates and decrease the emergence of resistance.” The future of interferon lambda Don’t expect interferon lambda to be available in the U.S. anytime soon, however, says Dr. David Apelian, interim CEO of Eiger BioPharmaceuticals. After the company first analyzed the data, it petitioned the FDA for emergency use authorization last spring. But after months of discussion, the FDA turned down the request in September because the study was not conducted in the U.S., and asked for such a study to qualify the drug for consideration under emergency use authorization. Apelian says that would be too time consuming and expensive for the company in the near term. “Any option that would satisfy the FDA’s request would probably be a costly and multi-year exercise,” he says. “And given the reduced sense of urgency from the federal government about COVID-19, the EUA path looks less likely today than it did six months ago.” Instead, the company is looking for faster approval outside of the U.S., since it says it already has 100,000 doses ready to distribute and the capacity to quickly manufacture 10 million more. “China and Australia appear to have the highest level of concern about the current state of the pandemic, so they are the most notable,” says Apelian of Eiger’s potential next targets.