If people with stiff and worn blood vessels use 20 milligrams of the Q10 variant MitoQ every day, their blood vessels appear to rejuvenate. The supplementation makes the blood vessels become smoother, and also reduces the cardiovascular damage that the 'bad cholesterol' LDL can cause. This is evident from a small human study that American researchers will soon publish in Hypertension. MitoQ MitoQ is also called mitoquinol or mitochondrial matrix-targeted ubiquinol. MitoQ is a variant of Q10 that is better absorbed by cells by the presence of a tetraphenylphosphonium group [on the right in the structural formula below]. This tetraphenylphosphonium group enhances the ability of the molecule to penetrate the membranes of cells and the mitochondria. In healthy cells Q10 is mainly found in the membranes of the mitochondria. There the Q10 molecule capture electrons that are released during the conversion of nutrients into energy, and ensures that energy production can continue. Aging and physiological stress reduce the concentration of Q10 molecules, and therefore some researchers suspect that supplementation with Q10 may slow down the aging process. In in vitro studies, MitoQ extends the life span of cells. [Aging Cell. 2003 Apr;2(2):141-3.] According to animal studies, MitoQ may protect against Alzheimer's disease [J Neurosci. 2011 Nov 2;31(44):15703-15.] [Free Radic Biol Med. 2014 Jun;71:390-401.], liver fibrosis [Int J Physiol Pathophysiol Pharmacol. 2016 Apr 25;8(1):14-27.], muscle damage by type-2 diabetes [Br J Nutr. 2016 Apr 14;115(7):1155-66.], anxiety [Neuropsychopharmacology. 2016 Jun;41(7):1751-8.] and heart failure [Free Radic Biol Med. 2018 Mar;117:18-29.]. Study Human research into the effects of MitoQ is not yet as much. The study on which this message goes is, as far as we know, the first. It is partly funded by the New Zealand MitoQ Limited [mitoq.com], but the American government was the main sponsor. In animal studies, supplementation with MitoQ rejuvenates the arteries. [J Appl Physiol (1985). 2017 Oct 26:jap006702017.] Blood vessels become stiffer due to aging, but supplementation with MitoQ reverses that process. American physiologists at the University of Colorado Boulder wondered whether MitoQ has the same effect in humans. The researchers divided 20 subjects aged 60-79 years with stiffened blood vessels into 2 groups. For 6 weeks they gave one group 20 milligrams of MitoQ every day - if you want to know exactly: the researchers use mitoquinol mesylate - and gave the other group a placebo. Results In the subjects who used MitoQ, the brachial artery flow-mediated dilation [BAFMD] was significantly increased after 6 weeks. This had not happened in the placebo group. The brachial artery flow-mediated dilation is a measure of the vitality and suppleness of the blood vessels. At the same time, supplementation with MitoQ had reduced the oxidation of the 'bad cholesterol' LDL. Especially in its oxidized form is LDL dangerous for the blood vessels. Conclusion "Here, we demonstrate for the first time that supplementation with the mitochondria-targeted antioxidant MitoQ is safe and well tolerated in late middle-aged and older adults, improves vascular endothelial function (likely by suppressing excess excess mitochondrial reactive oxygen species), reduces aortic stiffness in middle-aged and older adults with elevated initial levels, and decreases oxidized LDL, a circulating marker of oxidative stress", write the researchers. "Collectively, these findings establish the experimental basis for conducting a larger scale clinical trial in older adults or clinical populations, particularly those associated with endothelial dysfunction and elevated aortic stiffness." "In the broadest terms, our results provide initial support for the idea that MitoQ, and potentially other mitochondria-targeted antioxidants, may be an effective treatment for improving vascular function and possibly decreasing the risk of cardiovascular diseases and other clinical disorders of aging, including cognitive dysfunction and chronic kidney disease." Source: Hypertension. 2018;71:00-00.
What is it with your obsession with supplements and pills, Baron -- Is it your goal to live pass 100, 110, 120, 130+... I remember watching this documentary or news bit piece a long time ago, in the 90's I think...of a man who took like 40 or 50 pills a day...in an attempt to reduce aging.
Your body is one big hackable chemistry set. When you ingest certain foods and nutrients, and combine that with a little exercise, it can improve the longevity, but most importantly, the quality of your life. From what I see on Facebook, almost every single person I went to high school with is either obese, in poor health, or dead... and these are people in their late 40's. I'm passionate about health and fitness because I see that when people aren't mindful about what they put into their bodies, it eventually destroys them over time. It bothers me when I hear that people I once hung out with 20 years ago are now on 15 different medications for a variety of health problems because virtually all of those health issues are completely avoidable. Look, if a person wants to be on anti-depressants, blood pressure meds, statins for cholesterol, metformin to manage blood sugar, prednisone for arthritis, thyroid medication, and of course viagra because the side effects from all the above make it so he can't get his dick up, then he should by all means enjoy that shitty merry-go-round of a life. But I want everybody to know that it doesn't have to be that way. A small amount a daily exercise combined with mindful eating and scientifically proven supplements WILL IMPROVE THE QUALITY OF YOUR LIFE. You can literally shave 10 - 15 years off of your age in terms of how you feel just by making small changes to your daily routine. So yeah, I'm obsessed with this stuff because I hate seeing everyone around me sick, overweight and in constant pain.
Saw it on Amazon. Expensive - 60$ a jar, but the real issue is that the estimated shipping as of today 4/23 is end of May beginning of June. Holy crap.
I agree, and have made the same observation about my friends. But on the point of supplements, I found this one intriguing and so wrote to the scientist I consult on such matters. Here is what he had to say about MitoQ: There is a difference between statistical significance and clinical significance. In this study they used ultrasound to measure how arteries in the arm expand and contract in response to blood flow...this is a risk factor for arteriosclerosis but what we would really like to see is whether this supplement actually reduces cardiovascular events. The theory is that MitoQ is absorbed from the digestive tract more readily than CoQ10, which appears to be true. So it is more likely to make it into mitochondria in cells where it can act as an antioxidant. But until there is a trial that shows a clinical benefit it is premature to recommend this supplement.
I understand where he's coming from but just be aware that virtually all of the new supplement studies I post are going to be in the exact same category: Shows promise but not tested via rigorous human clinical trials yet. The medical community is usually 10 - 15 years behind so I wouldn't hold my breath that there will be any large-scale clinical trial data for MitoQ in the near future.
If I ever see Mito Q in the Walmart vitamin/supplement section lane, I'll buy it. I have tried virtually every vitamin and herb and mineral and fitness supplement available there.
I know. But I also remember all kinds of supplements over the years that were long on promise but short on delivery. Remember, say, chromium picolinate? I'm not suggesting MitoQ falls into that category, but you can understand why I might be a bit jaded. One could argue that some supplement companies thrive on the confirmation delay and probably view it as their window of opportunity. But I have no problem being pleasantly surprised.
It is all of interest, so no information is turned away, but: Ideally, instead of or in addition to the placebo group, I would like to see the MitoQ results compared to regular CoQ10 supplements that have piperine added to the formula, of which there are some. Piperine/black pepper extract, as you know is added to tumeric, q10 etc to increase absorption, and quite effectively so. Some coq10 formulas already have it. In other words, what is the statistical and clinical difference between MitoQ and the regular CoQ in the most absorbable form? Not just the difference between MitoQ and a non CoQ placebo. Especially in comparison with the most highly absorptive/ absorbable, whatever, CoQ, ie, with piperine. My never-humble opinion, is that, a little coq10 (with piperine either in your product or taken separately) and also taking a PQQ supplement at the same time is about the best you can do for your mitochondria at this time. If I had to bet, I would expect that combo to outperform the MitoQ product in regard to mitochondrial energy production, anti-oxidant value, etc. What gets studied often depends on who pays for it. EGCG is also something to throw in too if you are interested in mito health. Its concentrated green tea extract, and there are all the pubmed articles and others needed to give you more pointers and the studies behind it. Methinks anyway. also, just tossing this link in for those who did not follow my piperine rap. https://www.ncbi.nlm.nih.gov/pubmed/10715596
I finally got this about 10 days or so ago. I see no effect on my health whatsoever. Am I supposed to have more energy from it? Better sleep? The only effect I've noticed is that I feel like crap, like I'm coming down with some flu or something, if I take two of them in the morning. But this could have been a coincidence as maybe I was coming down with something. However, I skipped two days then tried two in the morning and again felt like I was coming down with something. Taking one in the morning is fine, but I don't feel like there is anything positive from it.