High LDL Cholesterol Is Not A Health 'Problem' & Other Facts

Discussion in 'Chit Chat' started by ByLoSellHi, Jan 8, 2009.

  1. "Eat vegetables, fruit, nuts, whole grains, fish and meat.'

    What's left not to eat :p
     
    #271     Feb 16, 2009
  2. http://truthabouttransfat.s3.amazonaws.com/content/pdf/TransFatFactSheet.pdf

    Datacruncher, if you do not know the food that have trans fat, here is a link. Animal product has little trans fat, and that trans fat from animals is (natural), and different than trans fat that man makes to keep food on a long shelf life.
    Animal products have saturated fat, (more calories) that if you eat too much you get fat, but in moderation meat has good protein.
     
    #272     Feb 16, 2009
  3. http://www.drug-injury.com/druginju...mvastatin-ezetimibe-induced-hepatic-fail.html



    New Reports Of Vytorin And Zetia Causing Liver Failure And Liver Disease

    2008 Medical Journal Articles Describe Two Cases; Authors Suggest Liver Testing At Start Of Therapy And When Titrating Dosage Is Necessary


    (Posted by Tom Lamb at DrugInjuryWatch.com)

    In December 2007 we told you about an article by New York Times (NYT) reporter Alex Berenson, "Data About Zetia Risks Was Not Fully Revealed", which revealed that Merck and Schering-Plough had conducted several studies of Zetia that raised the possibility that Zetia can cause liver damage when used long-term with statin drugs. The drug companies, however, decided not to publish the results of those Zetia studies, according to this NYT article.

    Now, in late summer 2008, two medical journal articles have been published which associate Zetia (ezetimibe) with liver failure and liver disease.

    From the September 1, 2008 edition of Pharmacotherapy we get an article, "Simvastatin-ezetimibe-induced hepatic failure necessitating liver transplantation", that discusses a case of liver failure involving Vytorin -- which is a combination of Zetia with the statin drug Zocor. The article points out that reports liver damage reports involving Zetia or Vytorin have not been widely published to date. It continues with one particular case report involving liver failure in a patient using Vytorin. From the abstract from this August 2008 Pharmacotherapy article:

    We describe a 70-year-old Hispanic woman who developed fulminant hepatic failure necessitating liver transplantation 10 weeks after conversion from simvastatin [or Zocor] 40 mg/day to simvastatin 10 mg-ezetimibe 40 mg/day [i.e., Vytorin]. The patient's lipid panel had been maintained with simvastatin for 18 months before the conversion without evidence of hepatotoxicity. A routine laboratory work-up 10 weeks after conversion revealed elevated serum aminotransferase levels. [The Vytorin] and escitalopram (which she was taking for depression) were discontinued, and other potential causes of hepatotoxicity were excluded. A repeat work-up revealed further elevations in aminotransferase levels, and liver biopsy revealed evidence of moderate-to-severe drug toxicity. She underwent liver transplantation with an uneventful postoperative course.... To our knowledge, this is the first case report of [Vytorin]-induced liver failure that resulted in liver transplantation.

    Thereafter, the article authors -- from the Division of Clinical and Administrative Pharmacy, at University of Iowa's College of Pharmacy -- posit a theory on how Vytorin and Zetia can cause liver failure:

    [Zetia] undergoes extensive glucuronidation by uridine diphosphate glucoronosyltransferases (UGT) in the intestine and liver and may have inhibited the glucuronidation of simvastatin hydroxy acid, resulting in increased simvastatin exposure and subsequent hepatotoxicity.... We postulate that the mechanism of the [Vytorin]-induced hepatotoxicity is the increased simvastatin exposure by ezetimibe inhibition of UGT enzymes.

    These authors conclude with the suggestion that liver function tests should be carefully monitored when starting Vytorin therapy and when titrating the Vytorin dosage.

    The second article, "Serious drug-induced liver disease secondary to ezetimibe", published in World Journal of Gastroenterology, August 28, 2008 edition, focuses on just Zetia. It reports the case of a woman who developed a "serious hepatocellular drug-induced liver disease" after taking Zetia 10 mg daily for a four month period, then recovered after she was taken off the Zetia. Based on this case, the authors concluded:

    [Zetia] may produce serious toxic hepatitis and prompt withdrawal is mandatory in case of a significant abnormality in liver testing after beginning or during treatment with [Zetia].

    We will continue to watch for reports of liver injury associated with Vytorin and Zetia. If you are aware of such a case, please share your information with us.

    September 04, 2008 in Drug Safety Alerts, Side Effect: Liver Failure (hepatitis, acute liver failure, liver transplant) | Permalink ShareThis
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    #273     Aug 20, 2009
  4. What else is there for those that won't eat a healthy diet?
     
    #274     Aug 20, 2009
  5. Death? Disease...and THEN death?

     
    #275     Aug 20, 2009
  6. Most have no clue what real food is, a hamburger & fries, that's not food it really isn't.of course i speak with literay license and tongue in cheek but the import remains fcatual
     
    #276     Aug 20, 2009
  7. 'Edible food like substances' now form well over half of the average American Child's diet, from Jello Pudding to 'Lunchables.'

    Our topsoil has been depleted of mineral and vitamin content due to soil erosion and the rotating crop methods used by big agri farms. Now, even when you eat fruits and vegetables, in an attempt to gain your health back, you don't get a fraction of the nutritional value that you were able to obtain years ago, with far less effort.

    It's quite tragic.

    http://www.foodincmovie.com/
     
    #277     Aug 20, 2009
  8. what lunchable do you recommend?
     
    #278     Aug 20, 2009
  9. Lucrum

    Lucrum

    I had a cheese burger for lunch.


    In the famous words of the Travelocity gnome: "Am I going to die?"
     
    #279     Aug 20, 2009