Anybody ever hear of this stuff? I was talking to a guy I hadn't seen in awhile and he has dropped like 25 pounds. Swears it was because of taking this stuff. Just thought I'd throw it out there if any of you are trying to drop some weight. Who knows. Pek? Freddie? ______________________ WebMD Garcinia Cambogia: Safe for Weight Loss? In this Article How It Works Type 2 Diabetes and High Cholesterol Possible Side Effects To Buy or Not to Buy Garcinia cambogia, a tropical fruit also known as the Malabar tamarind, is a popular weight-loss supplement. People say it blocks your body's ability to make fat and it puts the brakes on your appetite. It could help keep blood sugar and cholesterol levels in check, too. You'll find it in bottles on the shelf at the store as well as mixed with other ingredients in diet products. Does it live up to its hype? Maybe a little, but it might not be worth it. How It Works The active ingredient in the fruit's rind, hydroxycitric acid, or HCA, has boosted fat-burning and cut back appetite in studies. It appears to block an enzyme called citrate lyase, which your body uses to make fat. It also raises levels of the brain chemical serotonin, which may make you feel less hungry. But actual weight loss results aren't impressive. A review published in the Journal of Obesityfound that people who took garcinia cambogia in studies lost about 2 pounds more than people who didn't take it. The reviewers couldn't say for sure that the weight loss was because of the supplement. It could have been from the lower-calorie diet and exercise programs the people in the studies typically followed. Better studies are needed to find out if HCA really helps people lose a lot of weight and keep it off. Type 2 Diabetes and High Cholesterol Garcinia cambogia may make it easier for your body to use glucose, the sugar your cells need for energy. Mice that got garcinia cambogia in one study had lower insulin levels than mice that didn't. That's another reason, besides weight loss, that people with diabetes are interested in it. However, if you're taking garcinia cambogia along with a medication to control your blood sugar, your glucose could get dangerously low. Some research has found that garcinia cambogia can also improve cholesterol levels, lowering triglycerides and LDL (the "bad" cholesterol) and raising HDL (the "good" cholesterol). But you shouldn't use it if you're already on a prescription for your cholesterol. Continued Possible Side Effects When you take garcinia cambogia, you might get: Dizziness Dry mouth Headache Upset stomach or diarrhea In 2009, the Food and Drug Administration warned everyone to stop using a weight-loss product that contained garcinia cambogia because some people taking it got serious liver problems. The product had other ingredients, too, so it's not clear that garcinia cambogia was to blame. While some research suggests the supplement is safe for your liver, other research says no. Garcinia cambogia may interact badly with: Asthma and allergy medicines such as Accolate and Singulair Diabetes medicines, including pills and insulin Iron, for anemia Pain medicines Prescriptions for psychiatric conditions Statins, drugs that lower cholesterol Warfarin, a blood thinner You definitely don't want to use it when you're pregnant or nursing, or if you have kidney or liver problems. It is possible that manic symptoms may emerge as a side effect.