What's all this buzz I just started hearing about something called senolytic? A senolytic is among a class of small molecules under basic research to determine if they can selectively induce death of senescent cells and improve health in humans. Purpose - To delay, prevent, alleviate, or reverse age-related diseases. Mechanism - Induces death of senescent cells. Research Status - Preliminary research and early-stage human trials. Examples of Agents - Dasatinib and navitoclax. Related Concept - Senostatic, which means to suppress senescence. Senolytics are a class of drugs designed to selectively eliminate senescent cells, which are cells that have stopped dividing and contribute to aging and age-related diseases. The accumulation of these cells can lead to various health issues because they secrete pro-inflammatory factors that can damage surrounding tissues and promote chronic conditions. Mechanism of Action Senolytics target the so-called Senescent Cell Anti-Apoptotic Pathways (SCAPs), which allow senescent cells to survive despite signals that would typically induce death. By inhibiting these pathways, senolytic drugs can promote apoptosis, effectively clearing out dysfunctional cells from the body. Key Drugs and Their Applications Several notable senolytic agents include: Dasatinib and Quercetin: This combination has shown effectiveness in eliminating senescent cells and is being studied for various conditions, including idiopathic pulmonary fibrosis and age-related diseases. Navitoclax: An inhibitor of the BCL-2 family proteins, used to induce apoptosis in senescent cells. Fisetin: A flavonoid that has demonstrated senolytic properties in preclinical models and is being explored for treating conditions related to senescence, such as kidney fibrosis and muscular dystrophy. Current Research and Trials Recent pilot trials indicate that senolytic treatments could reduce inflammation and alleviate symptoms of frailty in humans. However, more extensive clinical trials are needed to further establish their safety and efficacy. Trials are underway for various conditions, including diabetes, Alzheimer's disease, and some cancers. Emerging Strategies Future directions in senolytic therapies are focusing on more targeted approaches, such as: Immunotherapies: Using CAR-T cell therapies to specifically target senescent cells based on unique markers expressed on their surface. Antibody-Drug Conjugates (ADCs): This method combines antibodies that target senescent cells with cytotoxic agents, allowing for precise killing of senescent cells while minimizing damage to healthy tissue. Conclusion The excitement surrounding senolytics stems from their potential to not just treat age-related diseases by removing dysfunctional cells but also to promote healthy aging. As research progresses, senolytics could pave the way for groundbreaking therapies aimed at improving healthspan and combating age-associated ailments.
For goodness sake, stop eating unnatural, drugs, synthetic, Frankenstein, chemically, and biologically altered food! Those who live beyond 100 years ago didn't take senolytics. They eat healthy natural food. When are you going to eat healthy natural food? Eating Healthier ---> Eating UNHealthier
I changed the recipe a bit by subbing anchovies for sardines and it was good. I am going to use anchovies from now on.
Fisetin and quercetin are just OTC supplements rather than "drugs." or requiring a prescription. They are flavonoids from sources such as strawberries, apples, etc. There are decent studies on pubmed and elsewhere regarding their senolytic activity.
Large-scale, long-term clinical trials could provide a clearer understanding of their safety and effectiveness.