I forgot to highlight another important issue from the above article that the article didn't mention because it didn't want to make it political... Trump Administration The federal government has been distributing monoclonal antibody drugs to the states since last winter but the treatments were underused due to lack of awareness from physicians, low interest among the public and the logistics of setting up areas to give them to patients via IV infusion. Also, persistent testing delays meant many people didn’t even get their results for seven days or longer, and clinics were focused on the upcoming vaccines or managing the winter surge of cases. Biden Administration Since then, many cities have set up alternative locations to administer the drugs and offer vaccines. The treatments are free for most patients, largely because the federal government has been actively involved in securing and distributing them. wrbtrader
But but but @Buy1Sell2 recently stated in this thread that the thread is not anti-vaccine. He then states it's a thread about anti-mandates even though there are no anti-mandate discussions and it's a thread that he did not start. wrbtrader
Treatments for COVID-19 July 12, 2021 What helps, what doesn't, and what's in the pipeline Most people who become ill with COVID-19 will be able to recover at home. Some of the same things you do to feel better if you have the flu — getting enough rest, staying well hydrated, and taking medications to relieve fever and aches and pains — also help with COVID-19. Beyond that, the FDA has also authorized treatments that may be used for people who have been hospitalized with COVID-19 and other medications to curb the progression of COVID-19 in people who are not hospitalized but who are at risk for developing severe illness. Scientists continue working hard to develop other effective treatments. What therapies might help people with severe COVID-19 prior to hospitalization? In November 2020, the FDA granted emergency use authorization to two monoclonal antibody treatments (bamlanivimab, made by Eli Lilly; and a combination of casirivimab and imdevimab, made by Regeneron). Both treatments have been approved for non-hospitalized adults and children over age 12 with mild to moderate COVID-19 symptoms who are at risk for developing severe COVID-19 or being hospitalized for it. In these patients, the approved treatments can reduce the risk of hospitalization and emergency room visits. These therapies must be given intravenously (by IV) soon after developing symptoms. If you are recovering at home, these measures can help reduce symptoms: While you don't need to stay in bed, you should get plenty of rest. Stay well hydrated. To reduce fever and ease aches and pains, take acetaminophen. Be sure to follow directions. If you are taking any combination cold or flu medicine, keep track of all the ingredients and the doses. For acetaminophen, the total daily dose from all products should not exceed 3,000 milligrams. What medications can doctors use for people hospitalized with COVID-19? Dexamethasone Many doctors, including those in the United States, have been treating very ill COVID-19 patients with corticosteroids since the pandemic began. It makes biologic sense for those patients who have developed a hyper-immune response (a cytokine storm) to the viral infection. In these cases, it is the immune system's overreaction that is damaging the lungs and other organs, and too often leading to death. Dexamethasone and other corticosteroids (prednisone, methylprednisolone) are potent anti-inflammatory drugs. They are readily available and inexpensive. The NIH COVID-19 treatment guidelines recommend the use of dexamethasone in certain people hospitalized with severe COVID-19. The recommendation was based on results from the RECOVERY trial. In the study, more than 6000 patients hospitalized with COVID-19 randomly received either dexamethasone or standard treatment. Patients who required supplemental oxygen or ventilators and who received dexamethasone were less likely to die within 28 days than those who received standard care. Dexamethasone did not have a benefit in patients who did not need respiratory support. Tocilizumab The FDA has granted emergency use authorization (EUA) for tocilizumab (Actemra) for the treatment of hospitalized adults and children ages 2 years and older who are receiving systemic corticosteroids such as dexamethasone, and who require supplemental oxygen, mechanical ventilation, or a heart-lung bypass machine, also known as extracorporeal membrane oxygenation (ECMO). Tocilizumab is a monoclonal antibody, already FDA-approved to treat several autoimmune diseases. Some COVID patients get sicker because of an overreaction of the body’s immune response (a cytokine storm) to the viral infection. When this happens, the body overproduces interleukin-6 (IL-6) — a protein involved in inflammation — in lung cells. Tocilizumab blocks the action of IL-6, and thereby dampens the exaggerated immune system response. The EUA was based on four clinical trials of hospitalized patients with COVID-19, which compared the use of tocilizumab plus routine care for COVID-19 (including corticosteroid therapy) to usual care alone. Through 28 days of follow up, tocilizumab plus usual care reduced the risk of death and the risk of being placed on a ventilator, and decreased the amount of time patients remained in the hospital, compared to usual care alone. Tocilizumab is not authorized for use in non-hospitalized patients with COVID-19. Remdesivir In October 2020, the FDA approved the antiviral drug remdesivir to treat COVID-19. The drug may be used to treat adults and children ages 12 and older and weighing at least 88 pounds, who have been hospitalized for COVID-19. Clinical trials suggest that in these patients, remdesivir may modestly speed up recovery time. Baricitinib in combination with remdesivir In November 2020, the Food and Drug Administration (FDA) issued an Emergency Use Authorization (EUA) for the use of baricitinib in combination with remdesivir in hospitalized adults and children two years and older who require respiratory support. However, there is not yet enough evidence to support the use of this therapy instead of dexamethasone with or without remdesivir. Anticoagulation drugs ("blood thinners") Almost all people admitted to the hospital with COVID receive medications to help prevent blood clots. Doctors usually prescribe low dose heparin or enoxaparin. However, some patients require full doses of anticoagulants if they already have developed blood clots or have a high risk of doing so. Doctors always need to balance the risk of dangerous bleeding when prescribing full doses. What are monoclonal antibodies? Can they help treat COVID-19? Three monoclonal antibody treatments for COVID-19 have been granted emergency use authorization (EUA) by the FDA. The treatments may be used to treat non-hospitalized adults and children over age 12 with mild to moderate symptoms who have recently tested positive for COVID-19, and who are at risk for developing severe COVID-19 or being hospitalized for it. This includes people over 65, people with obesity, and those with certain chronic medical conditions. Newer research suggests that monoclonal antibody treatment may also help to save lives in a specific subgroup of hospitalized COVID-19 patients. Monoclonal antibodies are manmade versions of the antibodies that our bodies naturally make to fight invaders, such as the SARS-CoV-2 virus. All three of the FDA-authorized therapies attack the coronavirus's spike protein, making it more difficult for the virus to attach to and enter human cells. The monoclonal antibody treatments that have EUA approval are: a combination of casirivimab and imdevimab, called REGN-COV, made by Regeneron; a combination of bamlanivimab and etesevimab, made by Eli Lilly; and sotrovimab, made by GlaxoSmithKline. These treatments must be given intravenously in a clinic or hospital. These treatments are not currently authorized for hospitalized COVID-19 patients or those receiving oxygen therapy. However, a pre-peer reviewed study, published in June 2021, showed promise for monoclonal antibody treatment in hospitalized COVID-19 patients who did not mount their own immune response. The study compared Regeneron’s monoclonal antibody treatment plus usual care to usual care alone in people hospitalized with COVID-19. In people who had not produced their own antibodies against the SARS-CoV-2 virus, monoclonal antibody treatment reduced the chances of dying by 20%. Monoclonal antibodies did not benefit people whose immune systems had already created antibodies in response to the virus. Monoclonal antibodies also can be used in combination with corticosteroids, such as dexamethasone, to dampen the immune response in very ill hospitalized patients. Some COVID patients get sicker because of an overreaction of the body’s immune response (a cytokine storm) to the viral infection. When this happens, the body overproduces interleukin-6 (IL-6) — a protein involved in inflammation — in lung cells. The FDA has granted EUA for tocilizumab (Actemra), a monoclonal antibody that blocks the action of IL-6, and thereby dampens the exaggerated immune system response. What is convalescent plasma? Does it help people with COVID-19? When people recover from COVID-19, their blood contains antibodies that their bodies produced to fight the coronavirus and help them get well. Antibodies are found in plasma, a component of blood. Convalescent plasma — literally plasma from recovered patients — has been used for more than 100 years to treat a variety of illnesses from measles to polio, chickenpox, and SARS. It is widely believed to be safe. In August 2020, the FDA issued an emergency use authorization (EUA) for convalescent plasma in patients hospitalized with COVID-19. A small but well-designed trial (randomized, double-blind, and placebo-controlled) was published in the New England Journal of Medicine in January 2021. The study only enrolled patients 65 years and older, and researchers screened the convalescent plasma to ensure it contained high levels of antibodies. The researchers found that patients who received convalescent plasma within three days of developing symptoms were 48% less likely to develop severe COVID illness compared to patients who received placebo. However, a meta-analysis of four peer-reviewed and published randomized clinical trials, published in JAMA, had less-promising results. The trials included in the analysis included 1060 patients with COVID-19 who received either convalescent plasma, a placebo, or standard treatment. Compared to placebo and standard treatment, convalescent plasma did not significantly improve risk of death, length of hospital stay, or the need for a ventilator. The study authors noted that the studies used for this analysis were small, and future clinical trials might suggest more benefit from the therapy. Who can donate plasma for COVID-19? In order to donate plasma, a person must meet several criteria. They have to have tested positive for COVID-19, recovered, have no symptoms for 14 days, currently test negative for COVID-19, and have high enough antibody levels in their plasma. A donor and patient must also have compatible blood types. Once plasma is donated, it is screened for other infectious diseases, such as HIV. Each donor produces enough plasma to treat one to three patients. Donating plasma should not weaken the donor's immune system nor make the donor more susceptible to getting reinfected with the virus. Why is it so difficult to develop treatments for viral illnesses? An antiviral drug must be able to target the specific part of a virus's life cycle that is necessary for it to reproduce. In addition, an antiviral drug must be able to kill a virus without killing the human cell it occupies. And viruses are highly adaptive. Because they reproduce so rapidly, they have plenty of opportunity to mutate (change their genetic information) with each new generation, potentially developing resistance to whatever drugs or vaccines we develop. In June 2021, the US government announced that it will invest more than $3 billion to develop antiviral medications to treat COVID-19 and to prepare for future pandemic threats. The money will be used to speed up the development and testing of antiviral drugs that are already in clinical trials, and for additional drug discovery with a focus on medications that can be taken by mouth. While COVID-19 vaccines remain central to protection, antiviral medications may be important for people whose bodies do not mount a strong response to the vaccine, who experience breakthrough infections, and for those who are unvaccinated. Is it safe to take ibuprofen to treat symptoms of COVID-19? Some French doctors advise against using ibuprofen (Motrin, Advil, many generic versions) for COVID-19 symptoms based on reports of otherwise healthy people with confirmed COVID-19 who were taking an NSAID for symptom relief and developed a severe illness, especially pneumonia. These are only observations and not based on scientific studies. The WHO initially recommended using acetaminophen instead of ibuprofen to help reduce fever and aches and pains related to this coronavirus infection, but now states that either acetaminophen or ibuprofen can be used. Rapid changes in recommendations create uncertainty. Since some doctors remain concerned about NSAIDs, it still seems prudent to choose acetaminophen first, with a total dose not exceeding 3,000 milligrams per day. However, if you suspect or know you have COVID-19 and cannot take acetaminophen, or have taken the maximum dose and still need symptom relief, taking over-the-counter ibuprofen does not need to be specifically avoided. Is hydroxychloroquine safe and effective for treating COVID-19? Hydroxychloroquine is primarily used to treat malaria and several inflammatory diseases, including lupus and rheumatoid arthritis. It is inexpensive and readily available. Early reports from China and France were promising, suggesting that patients with severe symptoms of COVID-19 improved more quickly when given hydroxychloroquine. However, in an article published in December 2020 in JAMA, researchers reported that hydroxychloroquine did not result in any clinical benefits for adults hospitalized with respiratory illness from COVID-19, compared with placebo. The NIH treatment guidelines recommend against the use of hydroxychloroquine for COVID-19, in both hospitalized and non-hospitalized patients. Does vitamin D protect against COVID-19? There is some evidence to suggest that vitamin D might help protect against becoming infected with, and developing serious symptoms of, COVID-19. We know, for example, that people with low vitamin D levels may be more susceptible to upper respiratory tract infections. One meta-analysis found that people who took vitamin D supplements, particularly those who had low vitamin D levels, were less likely to develop acute respiratory tract infections than those who didn't. Vitamin D may protect against COVID-19 in two ways. First, it may help boost our bodies' natural defense against viruses and bacteria. Second, it may help prevent an exaggerated inflammatory response, which has been shown to contribute to severe illness in some people with COVID-19. Our bodies make vitamin D when exposed to sunshine. Five to 10 minutes of sun exposure on some or most days of the week to the arms, legs, or back without sunscreen will enable you to make enough of the vitamin. Good food sources of vitamin D include fatty fish (such as tuna, mackerel, and salmon), foods fortified with vitamin D (such as dairy products, soy milk, and cereals), cheese, and egg yolks. The recommended dietary dose of vitamin D is 600 IU each day for adults 70 and younger and 800 IU each day for adults over 70. A daily supplement containing 1,000 to 2,000 IU of vitamin D is likely safe for most people. For adults, the risk of harmful effects increases above 4,000 IU per day. I've heard that high-dose vitamin C is being used to treat patients with COVID-19. Does it work? And should I take vitamin C to prevent infection with the COVID-19 virus? Some critically ill patients with COVID-19 have been treated with high doses of intravenous (IV) vitamin C in the hope that it will hasten recovery. However, there is no clear or convincing scientific evidence that it works for COVID-19 infections, and it is not a standard part of treatment for this infection. Regarding prevention, there is no evidence that taking vitamin C will help prevent infection with the coronavirus that causes COVID-19. While standard doses of vitamin C are generally harmless, high doses can cause a number of side effects, including nausea, cramps, and an increased risk of kidney stones. What is serologic (antibody) testing for COVID-19? What can it be used for? A serologic test is a blood test that looks for antibodies created by your immune system. There are many reasons you might make antibodies, the most important of which is to help fight infections. The serologic test for COVID-19 specifically looks for antibodies against the COVID-19 virus. Your body takes at least one to three weeks after you have acquired the infection to develop antibodies to this virus. For this reason, serologic tests are not sensitive enough to accurately diagnose an active COVID-19 infection, even in people with symptoms. However, serologic tests can help identify anyone who has recovered from coronavirus. This may include people who were not initially identified as having COVID-19 because they had no symptoms, had mild symptoms, chose not to get tested, had a false-negative test, or could not get tested for any reason. Serologic tests will provide a more accurate picture of how many people have been infected with, and recovered from, coronavirus, as well as the true fatality rate. Serologic tests may also provide information about whether people become immune to coronavirus once they've recovered and, if so, how long that immunity lasts. The accuracy of serologic tests varies depending on the test and when in the course of infection the test is performed. https://www.health.harvard.edu/diseases-and-conditions/treatments-for-covid-19 --------- wrbtrader
That guy is the dumbest and most disingenuous posters on this forum and its not due to lack of competition.
https://www.bnnbloomberg.ca/fda-issues-you-are-not-a-cow-warning-after-livestock-drug-use-1.1642703 FDA Issues ‘You Are Not a Cow’ Warning After Livestock Drug Use (Bloomberg) -- The U.S. Food and Drug Administration issued a strong and unusual warning on Saturday: “You are not a horse. You are not a cow. Seriously, y’all. Stop it.” The FDA was reacting to alarms from Mississippi, the state with the worst outbreak in the U.S., that people have been taking ivermectin to treat or prevent Covid-19. The drug is often used against parasites in livestock. On Friday, Mississippi’s health department issued a warning that more than 70% of recent calls to the state’s poison center came after people took ivermectin bought at livestock supply centers. Thomas Dobbs, the state health officer, said earlier this week he knew of only one hospitalization but was hearing reports of people taking the drug “as a preventative.” “Which I think is really kind of crazy, so please don’t do that,” he said at a press briefing. The health department warning said 85% of callers had mild symptoms but that one person was “was instructed to seek further evaluation due to the amount of ivermectin reportedly ingested.” Amid earlier reports of the drug’s use, the National Institutes of Health said most studies on ivermectin’s use against Covid-19 had “significant limitations” and said there was insufficient evidence to recommend either for or against the drug’s use in the pandemic. An FDA warning said that ivermectin “is not an anti-viral” and that “taking large doses of this drug is dangerous and can cause serious harm.” Though most often used in animals, the FDA said the drug has been approved in smaller doses in humans to treat two conditions caused by parasitic worms. Mississippi has the nation’s highest per capita outbreak and its lowest rate of vaccination. Though the pace of vaccination has picked up recently in Mississippi, 45.1% of people have received at least one dose compared with the national average of 60.5%, according to the Bloomberg Vaccine Tracker. ©2021 Bloomberg L.P.
It's a fast-growing problem in Mississippi about the use of Ivermectin especially in the poor regions of the state. Misinformation taking advantage of poor and desperate people. More problematic because most people in Mississippi did not know there were free Covid Medical Treatment Centers. Just as concerning, when Mississippi intentionally open up their state (removed face mask wear mandates) about 5 months ago with the CDC warning them not to do such along with warning a few other southern states about the Delta Variant... The CDC knows how unhealthy these states are and their poor ability to deal with a Pandemic of this magnitude. Mississippi still removed the face mask requirements and many other safety precautions for a Pandemic. Worst, they didn't even alert their residences that the free Covid Medical Treatment Centers were opening up and that it was also available at the hospitals. Now that the word is getting out about these free Covid Medical Treatment Centers...they then put some stupid restrictions like 65 years of age or older or diagnosed with a relevant pre-existing condition when their statistics show its the younger adults and children being targeted by the Delta Variant that's resulting in hospitalization, ICU admissions, and Deaths. https://www.clarionledger.com/story...-treatment-field-hospital-tuesday/8149801002/ The University of Mississippi Medical Center is offering free monoclonal antibody infusion treatment to Mississippians with symptomatic COVID-19 without the need for a doctor’s visit in an attempt to stave off additional hospitalizations and deaths in the depths of the delta surge. Monoclonal antibodies are a treatment for individuals newly infected with COVID-19, capable of stimulating a robust immune response to the virus. The antibody infusion targets the spike protein of SARS-CoV-2, blunting the severity of the infection even if treatment is received after a positive diagnosis and the onset of symptoms. Anyone may sign up for an appointment at UMMC’s new field hospital on campus in Garage B through this website. “We know that monoclonal antibody treatments may help patients avoid progression of mild symptoms into severe disease requiring hospitalization or leading to death,” wrote Dr. Alan Jones, UMMC’s associate vice chancellor for clinical affairs. “The availability of this clinic offers UMMC another tool in combating the devastating effects of this pandemic … alleviating the burden (on) the state’s hospital system.” Some restrictions apply to those signing up for the treatment. Prospective patients must complete a screening process to sign up for an infusion. Currently, candidates for monoclonal antibody treatment must be within 10 days of diagnosis, at least mildly symptomatic, and either 65 years of age or older or diagnosed with a relevant pre-existing condition. Numerous conditions qualify, including obesity, chronic kidney disease, cardiovascular or lung disease, as well as a variety of other potential complications for a COVID-19 diagnosis. https://www.mississippifreepress.or...tors-visit-to-curb-covid-19-hospitalizations/ Why are states like Mississippi being hit the hardest by Covid Delta Variant after opening up their state too soon against the advice of the CDC ??? They are one of the unhealthiest states with the worst outcomes in the United States of America for Covid...info known since the fall of 2020 but their idiotic Governor still removed their protections against Covid in early 2021. In fact, Mississippi has been known for poor treatment of any type of illness for many years long before the arrival of the Covid Pandemic. 10 states ranked lowest for health outcomes 1. Louisiana 2. Mississippi 3. Alabama 4. Arkansas 5. Kentucky 6. West Virginia 7. Tennessee 8. Oklahoma 9. South Carolina 10. Montana 10 states ranked lowest for clinical care 1. Texas 2. Mississippi 3. Nevada 4. Georgia 5. Oklahoma 6. Wyoming 7. Tennessee 8. Alabama 9. Arkansas 10. Florida https://www.beckershospitalreview.c...-healthiest-unhealthiest-states-for-2020.html #purestupidity wrbtrader