I haven't really noticed a major difference between VGA or DVI. I'm using nVidia FX dualhead cards with Dell 19" monitors. I have multiple monitors with some on VGA and some on DVI. I don't see a real difference in quality. However, DVI doesn't require any tweaking or adjusting. It is a consistent image. Given the low difference in price between DVI and VGA these days, I would go for DVI simply because it is the future. Who knows how long VGA will be around for??