"A" for sure...I could watch something go to the moon while I'm flat. Watching a paper profit melt away...not fun.
They are two sides of the same coin. Everything in trading is a compromise. Decide on your exit strategy and stick to it.
I have a greater fear of missing the big run. I believe that while more infrequent and more patience intensive, it is the more profitable route.
Some prefer to take both options. Half on target. Half on trailing stops. I tend to use targets when ranging and move to trailing when its broken out.
it would be interesting to see the profit performance of the two groups those who fear losing profits vs.those who fear missing the big run. which group is more likely to outperform?