The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro

Discussion in 'Wall St. News' started by easymon1, Apr 6, 2020.

  1. easymon1

    easymon1

    Farm Out. Horse Dewormer from any retail livestock supply, apple flavor, Ivermectin.
    https://www.horse.com/Search.aspx?query=ivermectin

    ivermectin98.jpg

    - - "samples treated with 5 μM ivermectin at 48 h, equating to a 99.98% reduction in"

    "...Ivermectin binds to and destabilises the Impα/β1 heterodimer thereby preventing Impα/β1 from binding to the viral protein (bottom) and preventing it from entering the nucleus. This likely results in reduced inhibition of the antiviral responses, leading to a normal, more efficient antiviral response."


    https://www.sciencedirect.com/science/article/pii/S0166354220302011
    ivermectin.jpg
    The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro
    Author links open overlay panelLeonCaly1Julian D.Druce1Mike G.Catton1David A.Jans2Kylie M.Wagstaff2
    https://doi.org/10.1016/j.antiviral.2020.104787
    Get rights and content
    Under a Creative Commons license
    open access
    Highlights

    • Ivermectin is an inhibitor of the COVID-19 causative virus (SARS-CoV-2) in vitro.
    • A single treatment able to effect ∼5000-fold reduction in virus at 48h in cell culture.
    • Ivermectin is FDA-approved for parasitic infections, and therefore has a potential for repurposing.
    • Ivermectin is widely available, due to its inclusion on the WHO model list of essential medicines.

    Abstract

    Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. We report here that Ivermectin, an FDA-approved anti-parasitic previously shown to have broad-spectrum anti-viral activity in vitro, is an inhibitor of the causative virus (SARS-CoV-2), with a single addition to Vero-hSLAM cells 2 hours post infection with SARS-CoV-2 able to effect ∼5000-fold reduction in viral RNA at 48 h. Ivermectin therefore warrants further investigation for possible benefits in humans.
    -

    Can We Get A YeeHawww
     
    Last edited: Apr 6, 2020
    piezoe likes this.
  2. keesa

    keesa

    Keyword: in vitra
    It means that it is years away from animal studies and clinical trial. Worthless for pandemic
     
  3. easymon1

    easymon1

    LOL, suit yourself.
     
  4. Turveyd

    Turveyd

    This will be over in 3months for everyone so never going to be ready in time, guess they was working on worst case like well everyone.
     
  5. easymon1

    easymon1

    Pegasus7.jpg

     
    Last edited: Apr 6, 2020
  6. easymon1

    easymon1

    ten x overshoot.jpg
    Barnes' report on American Countdown Show, cued to go...


    for dessert, from Legendary Casey Kasem's countdown, American Top 40, comes this heartfelt sentiment...
     
    Last edited: Apr 7, 2020
  7. Turveyd

    Turveyd


    Nice find, saying exactly what I'm saying.

    90% of deaths in italy aren't C19 and it's being looked into lol

    This is going to cause a shit storm.


    They went for everyone that gets will need hospital care which was just ridiculous.
     
  8. easymon1

    easymon1

  9. Turveyd

    Turveyd

  10. easymon1

    easymon1