https://scitechdaily.com/magnesium-magic-new-drug-delivers-weight-loss-even-on-sugary-fatty-diet/ Researchers at UT Health San Antonio, along with collaborators from the University of Pennsylvania and Cornell University, have developed a small-molecule drug called CPACC that limits magnesium transport in cellular power plants called mitochondria. The drug has been shown to prevent weight gain and adverse liver changes in mice on a high-sugar, high-fat diet. By reducing magnesium transport in the mitochondria, the drug enhances metabolism of sugar and fat, resulting in slimmer and healthier mice with no evidence of fatty liver disease. The researchers have filed a patent application for the drug, which has potential implications in reducing the risk of cardiometabolic diseases and liver cancer. Compound limits magnesium transport in cellular power plants called mitochondria. A small-molecule drug, CPACC, developed by researchers, has been shown to prevent weight gain and liver issues in mice by limiting magnesium transport in cellular power plants, thus improving metabolism and overall health. Researchers from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have developed a small-molecule drug that prevents weight gain and adverse liver changes in mice fed a high-sugar, high-fat Western diet throughout life. “When we give this drug to the mice for a short time, they start losing weight. They all become slim,” said Madesh Muniswamy, PhD, professor of medicine in the health science center’s Joe R. and Teresa Lozano Long School of Medicine. “A drug that can reduce the risk of cardiometabolic diseases such as heart attack and stroke, and also reduce the incidence of liver cancer, which can follow fatty liver disease, will make a huge impact.” — Madesh Muniswamy, PhD Findings by the collaborators, also from the University of Pennsylvania and Cornell University, were published recently in the high-impact journal Cell Reports. Muniswamy, director of the Center for Mitochondrial Medicine at UT Health San Antonio, is the senior author. Fourth most common element The research team discovered the drug by first exploring how magnesium impacts metabolism, which is the production and consumption of energy in cells. This energy, called ATP, fuels the body’s processes. Magnesium is the fourth most abundant cation, or positively charged ion, in the body after calcium, potassium, and sodium, and plays many key roles in good health, including regulating blood sugar and blood pressure and building bones. But the researchers found that too much magnesium slows energy production in mitochondria, which are cells’ power plants. “It puts the brake on, it just slows down,” said co-lead author Travis R. Madaris, doctoral student in the Muniswamy laboratory at UT Health San Antonio. Deleting MRS2, a gene that promotes magnesium transport into the mitochondria, resulted in more efficient metabolism of sugar and fat in the power plants. The result: skinny, healthy mice. Liver and adipose (fat) tissues in the rodents showed no evidence of fatty liver disease, a complication related to poor diet, obesity, and type 2 diabetes. Small-molecule agent The drug, which the researchers call CPACC, accomplishes the same thing. It restricts the amount of magnesium transfer into the power plants. In experiments, the result was again: skinny, healthy mice. UT Health San Antonio has filed a patent application on the drug. The mice served as a model system of long-term dietary stress precipitated by the calorie-rich, sugary, and fatty Western diet. The familiar results of this stress are obesity, type 2 diabetes, and cardiovascular complications. owering the mitochondrial magnesium mitigated the adverse effects of prolonged dietary stress,” said co-lead author Manigandan Venkatesan, PhD, postdoctoral fellow in the Muniswamy lab. Joseph A. Baur, PhD, of the University of Pennsylvania and Justin J. Wilson, PhD, of Cornell are among the collaborators. “We came up with the small molecule and Justin synthesized it,” Madaris said. Significant implications “These findings are the result of several years of work,” Muniswamy said. “A drug that can reduce the risk of cardiometabolic diseases such as heart attack and stroke, and also reduce the incidence of liver cancer, which can follow fatty liver disease, will make a huge impact. We will continue its development.”
Magnesium is important to heart health as well but not all Magnesium is created equal. Magnesium oxside is garbage and turns to shit, literally. Citrate a bit better but you need a lot of it as most is still passed through the bowels. A better quality chelated is what's needed as a supplement and nearly everyone needs to supplement as it's almost impossible to get the daily requirements from diet alone, especially considering our farming soil is so depleted that crops don't deliver what they used to in Magnesium or anything else. Magnesium, zinc and D3 along with proper gut health foods will change your life for the better.
Hmmm... along that line of thought, I wonder if magnesium supplementation is a bad idea for those trying to lose weight?
That’s what occurred to me as well. Meanwhile you will find sites that conclude (extra?) magnesium can aid in weight management. Perhaps there’s something I’m missing, and therefore failing to connect the two dots. For now I’ll just eat well and hope for the best.
I took 300mg daily magnesium for months because I had stress related issues. Weight wise I've seen no differences. Ain't got no weight problems.
@Frederick Foresight Do you think she might be taking magnesium? I hope this isn't an AI fake. www.facebook.com/reel/1367362530783895?mibextid=9drbnH&s=yWDuG2&fs=e