"When you create a calorie deficit you don't just want to lose weight, you want to lose fat. This is an especially important issue for those taking GLP-1 agonists. In the absence of a correct stimulus a significant amount of weight loss will come from your skeletal muscle. However, with a correct stimulus we can shunt almost all weight loss towards fat loss. This is why it is critical for those on GLP-1 agonists to be performing high intensity resistance exercise."