Cannabis helps protect against Covid? Lots of stories

Discussion in 'Chit Chat' started by KCalhoun, Jan 15, 2022.

  1. KCalhoun

    KCalhoun

  2. Bugenhagen

    Bugenhagen

    Smoked its a lung irritant and that won't be good, taken orally it could lead to similar incautious behaviors that increase the risk for those with dementia or the mentally handicapped.
     
    Last edited: Jan 15, 2022
  3. gwb-trading

    gwb-trading

    The cannabis industry enjoyed planting this Covid story. Please pass the…
     
    Bugenhagen and KCalhoun like this.
  4. gwb-trading

    gwb-trading

    Sisters of the Valley ‘Weed nuns’ praise study stating pot can prevent COVID-19
    https://nypost.com/2022/01/15/siste...s-praise-study-stating-pot-can-prevent-covid/

    A group of self-described “weed nuns” cheered a study that found cannabis may help prevent COVID-19 infections.

    “We are, naturally, pleased that science is catching up with ancient wisdom,” Sister Kate of the Sisters of the Valley told The Sun.

    An Oregon State University study, released last week, found two compounds in marijuana may bind to the COVID-19 spike protein, preventing its entry to healthy cells.

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    Sisters of the Valley “weed nuns” are praising a new Oregon State University study stating weed can prevent COVID-19.

    “It’s wonderful progress to have the scientific community say ‘we’re already determined that there are compounds in hemp that can prevent infection’, so now, we can just get on to studying dosage,” said the nun, whose legal name is Christine Meeusen said. “That’s progress.”

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    Dr. Richard van Breeman, of OSU’s Global Hemp Innovation Center, said that the two compounds, cannabigerolic and cannabidiolic acids, could help prevent and treat COVID-19.

    “They are not controlled substances like THC, the psychoactive ingredient in marijuana, and have a good safety profile in humans,” he added.

    Meeusen’s northern-California-based feminist collective — the Sisters of the Valley, which is unsurprisingly not affiliated with the Catholic Church — grows its own pot, which it uses to create holistic health products. It started with just 12 plants, but grew to over $1 million in annual revenue before the pandemic.

    “So we created something that is nonreligious, but it’s spiritual — and it’s very eco-feminist in nature.”

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  5. wrbtrader

    wrbtrader

    Ken,

    Stay away from Cannabis if you don't want to have any kids.

    I have a friend that's 52 years old and his wife is 40 years old...they don't want any kids. He sold his business so that they can retire early and bought a home in Mexico...a place they love to go to instead of spending their winters here in Canada.
    • They recently begin smoking Cannabis and noticed their sex drive reached incredible levels.
    Surprise, surprise, and surprise. She's now pregnant with triplets in the middle of a Pandemic.

    wrbtrader
     
    KCalhoun likes this.
  6. easymon1

    easymon1

    Abstract
    As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which cause COVID-19. Affinity selection-mass spectrometry was used for the discovery of botanical ligands to the SARS-CoV-2 spike protein.



    Isolated molecules that provide for the mechanism of claimed 'protection' could outcompete the infectuous molecules for the 'locks' that open the door for entry into cellular mechanisms of infection, the viral pathway, thereby reducing viral load on the host.

    Purification of the molecule of interest away from the remainder of the mixture, or production of a molecular mimic library which is competition tested for binding site 'blocking' ability would remove the entire 'get-high' angle of this method. "Protein folding problem"

    Standard procedure. It's used all the time in medicinal chemistry

    This tendency for molecules to compete for binding sites is the basis of the idea that fluoride outcompetes iodine for binding sites in the thyroid gland.

    Fluoride Exposure Induces Inhibition of Sodium/Iodide Symporter (NIS) Contributing to Impaired Iodine Absorption and Iodine Deficiency: Molecular Mechanisms of Inhibition and Implications for Public Health
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466022/
     
    Last edited: Jan 16, 2022
  7. gwb-trading

    gwb-trading

    Fact Check: Did Studies Show That Marijuana Prevents COVID Transmission?
    https://www.newsweek.com/fact-check...marijuana-prevents-covid-transmission-1671769

    Two scientific papers published this month have added to the growing body of evidence indicating that cannabinoids may hold significant antiviral potencies and could potentially be used to create a prophylactic treatment for Covid-19.

    The latest research into the impact of cannabinoid compounds on SARS-CoV-2 replication has generated a buzz on mainstream and social media, leading some users to claim that consumption of marijuana can help prevent or fight COVID infection.

    "All this time we've been listening to the CDC, we should have been eating CBD," ABC's Jimmy Kimmel said on his show last week.

    "Now, if you're skeptical about the science here, let me remind you, this study has been reviewed by the CDC's stoner nephew the THC," The Late Show host Stephen Colbert joked.





    Stoner humor aside, the news also fueled mal- and misinformation. Some accounts pounced on the reporting to promote products containing CBD, the non-psychoactive cannabis compound featured in the research.

    "We're celebrating that CBD is officially scientifically proven to prevent Covid and the vaccine isn't," one tweet marketing CBD oil falsely claimed.

    Since the start of the coronavirus pandemic, there has been a number of scientific studies exploring the potential links between cannabis and COVID-19, including a January 2021 study assessing antiviral potencies of cannabinoids against SARS-CoV-2 and an Israeli project to develop CBD-based treatments for the coronavirus in 2020.

    More recently, a study, conducted in conjunction with Oregon State University and published in the Journal of Natural Products on January 10, indicated that cannabis compounds can be used as a "therapeutic agent" to block the COVID-19 virus from entering the body.

    This week, a team of researchers from the University of Chicago claimed to have found evidence that cannabidiol (CBD) derived from a cannabis plant can inhibit infection by SARS-CoV-2 in human cells and in mice.

    But while these and other studies into potential preventative or therapeutic treatments against the virus are encouraging, the headline-grabbing aspects of the research tend to obscure critical information and nuance in the findings, often leading to the proliferation of false or misleading interpretations.

    As Newsweek previously reported, the peer-reviewed Journal of Natural Products found that "cannabigerolic acid (CBGA) and cannabidiolic acid (CBDA) prevented infection of human epithelial cells...and prevented entry of live SARS-CoV-2 into cells."

    But that conclusion came along with some major caveats, which poured cold water on the claims that recreational marijuana use is now "scientifically proven" to be effective at preventing COVID infection.

    For one, the study involved testing against two early COVID variants, Alpha and Beta, but provided no data about the effects on the now dominant Omicron variant. It was also conducted in vitro, meaning that it assessed the impact of cannabinoid acids from hemp on human cells in a clinical setting, which may not necessarily be replicated in human trials.

    The fact that the acid would need to be extracted from hemp leaves, as well as the high purity and quantity required for the effect to be tangible, ruled out the more widespread "methods of delivery," such as smoking or consuming edibles with marijuana.

    "Our infection inhibition assay results clearly indicate that CBDA and CBGA are both able to block cell entry by SARS-CoV-2. The concentrations needed to block infection by 50% of viruses is high but might be clinically achievable," the research authors explained, reiterating that any potential treatment should be combined with proper doses of the COVID vaccine.

    Meanwhile, the University of Chicago study, published on January 20 in Science Advances, claims in the abstract that "cannabidiol (CBD) inhibits infection of SARS-CoV-2 in cells and mice," offering another cause for cautious optimism. But it, too, does not go so far as to justify the claims that marijuana products can prevent COVID infection, nor that they are "more effective than vaccines."

    This research, which included both cell-based findings, pre-clinical studies and analysis of patient data showing the link between CBD consumption and SARS-CoV-2 infection rate, concluded that "CBD and its metabolite 7-OH-CBD can block SARS-CoV-2 infection at early and even later stages of infection."

    It also supported previous findings that the substance "suppresses cytokine activation in response to viral infection, reducing the likelihood of immune cell recruitment and subsequent cytokine storms within the lungs and other affected tissues."

    But the authors also highlighted a number of issues, both with regards to using existing commercial products for prevention and treatment of COVID, and developing new ones.

    While CBD-containing products are available on the market, they note that these products vary vastly in quality, CBD content, and their pharmacokinetic properties after oral administration, which is mostly unknown. Additionally, the quantity and purity of CBD in the existing products were deemed insufficient, while additional compounds found in cannabis such as THC could be detrimental to the antiviral effects.

    "This essentially eliminates the feasibility of marijuana serving as an effective source of antiviral CBD, in addition to issues related to its legal status," the study concludes, noting that "other means of CBD administration such as vaping and smoking raise additional concerns about potential lung damage."

    While cautioning against the use of CBD in "presently available formulations including edibles, inhalants or topicals as a preventative or treatment therapy," the researchers call for further studies and clinical trials to be conducted in order to establish the optimal means of the compound's delivery to patients.

    The Ruling: Mostly False.

    [​IMG]

    A number scientific studies into the effects of CBD or compounds derived from cannabis on SARS-CoV-2 virus transmission have indeed shown promising results. These studies, however, did not broadly assess possible medicinal qualities or antiviral properties of the marijuana plant—which contains many other compounds in addition to CBD—and its recreational use. Researchers also explicitly warned against the use of existing means of CBD delivery, such as edibles or inhalation, for treatment or prevention purposes, and highlighted the importance of vaccinations against COVID.
     
  8. WardMoore

    WardMoore

    Well, I read that cannabis helps with Covid today for the first time. Thanks for providing links to those resources, after work today I'm going to read them.
    And is here someone who can prove that theory, or deny, based on their own opinion?